These mice are specifically designed for use in computer games. They typically employ a wider array of controls and buttons and have designs that differ radically from traditional mice. They may also have decorative monochrome or programmable RGB LED lighting. The additional buttons can often be used for changing the sensitivity of the mouseor they can be assigned (programmed) to macros (i.e., for opening a program or for use instead of a key combination).

It is also common for game mice, especially those designed for use in real-time strategy games such as StarCraft, or in multiplayer online battle arena games such as League of Legends to have a relatively high sensitivity, measured in dots per inch (DPI),^[89] which can be as high as 25,600.^[90] DPI and CPI are the same values that refer to the mouse’s sensitivity. DPI is a misnomer used in the gaming world, and many manufacturers use it to refer to CPI, counts per inch.

Some advanced mice from gaming manufacturers also allow users to adjust the weight of the mouse by adding or subtracting weights to allow for easier control. Ergonomic quality is also an important factor in gaming mouse, as extended gameplay times may render further use of the mouse to be uncomfortable. Some mice have been designed to have adjustable features such as removable and/or elongated palm rests, horizontally adjustable thumb rests and pinky rests. Some mice may include several different rests with their products to ensure comfort for a wider range of target consumers.